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Article

Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome.

Cell research - 1 Dec 2012

Llano Anuska, Brander Christian

Abstract excerpt

The potentially life-threatening adverse reactions to Abavacir (ABC), a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection, have been known for several years to be limited to individuals expressing the HLA-B57:01 gene. Why the ABC hypersensitivity syndrome is only seen in HLA-B57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however...

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Identifiers

PMID: 22777424
DOI: 10.1038/cr.2012.105
PMCID: PMC3515749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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