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Article

Abacavir adverse reactions related with HLA-B*57: 01 haplotype in a large cohort of patients infected with HIV.

Pharmacogenetics and genomics - 1 Oct 2020

Quiros-Roldan Eugenia, Gardini Giulia, Properzi Martina, Ferraresi Alice, Carella Graziella, Marchi Alessandro, Malagoli Alberto, Focà Emanuele, Castelli Francesco

Abstract excerpt

OBJECTIVE: Carriage of human leukocyte antigen (HLA)-B*57:01 allele increases the risk of abacavir hypersensitivity reaction. Therefore, since 2008 HIV treatment guidelines recommend HLA-B*57:01 screening before abacavir administration, greatly reducing hypersensitivity reaction rate. However, clinically suspected abacavir-related hypersensitivity reactions are described in allele non-carriers. Major aim of this...

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PMID: 32453265
DOI: 10.1097/FPC.0000000000000409

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