Article
A motor-driven mechanism for cell-length sensing.
Cell reports - 28 Jun 2012
Rishal Ida, Kam Naaman, Perry Rotem Ben-Tov, Shinder Vera, Fisher Elizabeth M C, Schiavo Giampietro, Fainzilber Mike
Abstract excerpt
Size homeostasis is fundamental in cell biology, but it is not clear how large cells such as neurons can assess their own size or length. We examined a role for molecular motors in intracellular length sensing.Computational simulations suggest that spatial information can be encoded by the frequency of an oscillating retrograde signal arising from a composite negative feedback loop between bidirectional...
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