Myonuclear content regulates cell size with similar scaling properties in mice and humans

Abstract excerpt

Abstract Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number ( N ) adheres to the relationship N = aV b where V is the cytoplasmic volume. N invariably scales sublinearly to V ( b < 1), making larger...

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