Article
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform.
Advanced healthcare materials - 1 May 2022
Hagemann Cathleen, Moreno Gonzalez Carmen, Guetta Ludovica, Tyzack Giulia, Chiappini Ciro, Legati Andrea, Patani Rickie, Serio Andrea
Abstract excerpt
Stem cell-based experimental platforms for neuroscience can effectively model key mechanistic aspects of human development and disease. However, conventional culture systems often overlook the engineering constraints that cells face in vivo. This is particularly relevant for neurons covering long range connections such as spinal motor neurons (MNs). Their axons extend up to 1m in length and require a complex...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.