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Article

A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing.

Journal of cell science - 1 Mar 2023

Di Pizio Agostina, Marvaldi Letizia, Birling Marie-Christine, Okladnikov Nataliya, Dupuis Luc, Fainzilber Mike, Rishal Ida

Abstract excerpt

Size homeostasis is a fundamental process in biology and is particularly important for large cells such as neurons. We previously proposed a motor-dependent length-sensing mechanism wherein reductions in microtubule motor levels would be expected to accelerate neuronal growth, and validated this prediction in dynein heavy chain 1 Loa mutant (Dync1h1Loa) sensory neurons. Here, we describe a new mouse model with a...

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Identifiers

PMID: 36218033
DOI: 10.1242/jcs.260220
PMCID: PMC9687604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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