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Article

The number of CAG repeats within the normal allele does not influence the age of onset in Huntington's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2011

Klempíř Jiří, Zidovská Jana, Stochl Jan, Ing Věra Kebrdlová, Uhrová Tereza, Roth Jan

Abstract excerpt

Huntington's disease (HD) is caused by the expansion of the number of CAG repeats on the chromosome 4p16.3, which results in elongated glutamine tract of huntingtin. The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effect on the clinical onset of HD. We hypothesized that in patients with identical number of CAG repeats within the mutant allele,...

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PMID: 21322024
DOI: 10.1002/mds.23436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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