Article

Role of mast cells in endomicrobial sepsis revisited: Mast cell-deficient mice show normal immunological protection

2025-03-13

Abstract excerpt

Kit -mutant mice are highly susceptible to polymicrobial sepsis elicited by cecal ligation and puncture (CLP). This vulnerability has been attributed to the mast cell deficiency of Kit mutants, suggesting key roles of mast cells in antibacterial defense. We show that mice lacking mast cells but wild-type for Kit are as resistant to sepsis as mast cell-proficient mice, excluding mast cells as protective factor. I...

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Literature Corpus work: 509a783c-f919-5cde-9184-9faf9e16d8e6
DOI: 10.1101/2025.03.07.642033

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