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Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

24 May 2019

Abstract excerpt

Candida albicans is a fungal pathobiont, able to cause epithelial cell damage and immune activation. These functions have been attributed to its secreted toxin, candidalysin, though the molecular mechanisms are poorly understood. Here, we identify epidermal growth factor receptor (EGFR) as a critical component of candidalysin-triggered immune responses. We find that both C. albicans and candidalysin activate...

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PMID: 31127085
DOI: 10.1038/s41467-019-09915-2

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