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Article

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2005

Lee Janet S, Frevert Charles W, Matute-Bello Gustavo, Wurfel Mark M, Wong Venus A, Lin Shu-Min, Ruzinski John, Mongovin Steve, Goodman Richard B, Martin Thomas R

Abstract excerpt

We examined the role of Toll-like receptor (TLR)-4 in modifying the lung inflammatory response and its effects on the bacterial recovery from the lungs following inhaled Escherichia coli in two different strains of TLR-4 mutant mice that are hyporesponsive to LPS. The C57BL/10ScN(tlr4(lps-del)) mice containing a deletion mutation in the TLR-4 gene showed lower proinflammatory cytokine levels, lower lung MPO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16024722
DOI: 10.1152/ajplung.00196.2005

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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