Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases.

doi:10.1534/g3.116.028563

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Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases.

G3 (Bethesda, Md.) - 7 Jul 2016

Murk William, DeWan Andrew T

Abstract excerpt

The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets. We aimed to use data from the Resource for Genetic Epidemiology Research on Adult Health and Aging (GERA) study to search for SNP-SNP interactions associated with 10 common...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Aging
Alleles
Asthma
Case-Control Studies
Datasets as Topic
Depression
Diabetes Mellitus, Type 2
Dyslipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epistasis, Genetic

Female

Gene Frequency

Genome, Human

Genome-Wide Association Study

Heart Diseases

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PMID: 27185397
DOI: 10.1534/g3.116.028563
PMCID: PMC4938657

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