Article
Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells.
Molecular and cellular biochemistry - 1 Apr 2012
Han Mingli, Liu Manran, Wang Yimeng, Mo Zhiqiang, Bi Xiaokai, Liu Zhirong, Fan Yuanming, Chen Xin, Wu Chengyi
Abstract excerpt
MiR-21 is known to play an important role in the development and progression, including migration and invasion, of many malignancies including breast cancer. Accumulating evidence suggest that the induction of epithelial-mesenchymal transition (EMT) phenotype and acquisition of cancer stem cell (CSC) characteristics are highly interrelated, and contribute to tumorigenesis, tumor progression, metastasis, and...
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