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Article

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

Scientific reports - 6 Sept 2016

Yan Li, Cao Rui, Liu YuanBo, Wang LianZhao, Pan Bo, Lv XiaoYan, Jiao Hu, Zhuang Qiang, Sun XueJian, Xiao Ran

Abstract excerpt

Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNAs microarray analysis we found mir-21-5p was significantly up-regulated in keloid epidermis. To...

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Share to Aldehyde Dehydrogenase 1 Family
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyaluronan Receptors

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Source

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Identifiers

PMID: 27596120
DOI: 10.1038/srep28281
PMCID: PMC5011940

Genes

PTEN

Provenance

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MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.PMID 27596120Read ↗

MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling PathwaySemantic proximity Read ↗

MicroRNA-21 Affects Proliferation and Apoptosis by Regulating Expression of PTEN in Human Keloid FibroblastsSemantic proximity Read ↗

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21Semantic proximity Read ↗

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar FibroblastsSemantic proximity Read ↗

MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseasesSemantic proximity Read ↗

Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathwaySemantic proximity Read ↗

Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.Semantic proximity Read ↗

Long non-coding RNA HOXA11-AS accelerates the progression of keloid formation via miR-124-3p/TGFβR1 axis.Semantic proximity Read ↗

Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblastsSemantic proximity Read ↗

Microrna-21: A Central Regulator of Fibrotic Diseases Via Various TargetsSemantic proximity Read ↗

MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloidSemantic proximity Read ↗

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