Article
The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI.
Translational psychiatry - 3 Jul 2012
Whalley H C, Papmeyer M, Sprooten E, Romaniuk L, Blackwood D H, Glahn D C, Hall J, Lawrie S M, Sussmann Je, McIntosh A M
Abstract excerpt
Genome-wide association studies (GWAS) have demonstrated a significant polygenic contribution to bipolar disorder (BD) where disease risk is determined by the summation of many alleles of small individual magnitude. Modelling polygenic risk scores may be a powerful way of identifying disrupted brain regions whose genetic architecture is related to that of BD. We determined the extent to which common genetic...
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