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Article

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.

Basic research in cardiology - 1 Sept 2012

Lygate Craig A, Medway Debra J, Ostrowski Philip J, Aksentijevic Dunja, Sebag-Montefiore Liam, Hunyor Imre, Zervou Sevasti, Schneider Jurgen E, Neubauer Stefan

Abstract excerpt

The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK(-/-)) have previously been described, but exhibit an unexpectedly mild phenotype of compensated left ventricular (LV) hypertrophy. We hypothesised that heart failure would develop with age and performed...

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Identifiers

PMID: 22760499
DOI: 10.1007/s00395-012-0276-2
PMCID: PMC3442167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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