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Article

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.

Journal of molecular and cellular cardiology - 1 Jun 2012

Fraysse Bodvaël, Weinberger Florian, Bardswell Sonya C, Cuello Friederike, Vignier Nicolas, Geertz Birgit, Starbatty Jutta, Krämer Elisabeth, Coirault Catherine, Eschenhagen Thomas, Kentish Jonathan C, Avkiran Metin, Carrier Lucie

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in MYBPC3 encoding cardiac myosin-binding protein C (cMyBP-C). The mechanisms leading from gene mutations to the HCM phenotype remain incompletely understood, partially because current mouse models of HCM do not faithfully reflect the human situation and early hypertrophy confounds the interpretation of functional alterations. The goal of this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22465693
DOI: 10.1016/j.yjmcc.2012.03.009
PMCID: PMC3370652

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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