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Article

Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.

Cardiovascular research - 1 Jul 2016

Massengill Michael T, Ashraf Hassan M, Chowdhury Rajib R, Chrzanowski Stephen M, Kar Jeena, Warren Sonisha A, Walter Glenn A, Zeng Huadong, Kang Byung-Ho, Anderson Robert H, Moss Richard L, Kasahara Hideko

Abstract excerpt

AIMS: Under pressure overload, initial adaptive hypertrophy of the heart is followed by cardiomyocyte elongation, reduced contractile force, and failure. The mechanisms governing the transition to failure are not fully understood. Pressure overload reduced cardiac myosin light chain kinase (cMLCK) by ∼80% within 1 week and persists. Knockdown of cMLCK in cardiomyocytes resulted in reduced cardiac contractility...

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Identifiers

PMID: 27025239
DOI: 10.1093/cvr/cvw069
PMCID: PMC4909160

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