Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.

Neuropathology and applied neurobiology - 1 Jun 2013

Gessi M, Hammes J, Lauriola L, Dörner E, Kirfel J, Kristiansen G, zur Muehlen A, Denkhaus D, Waha A, Pietsch T

Abstract excerpt

AIM: Primary melanocytic tumours are uncommon neoplasms of the central nervous system. Although similarities with uveal melanomas have been hypothesized, data on their molecular features are limited. METHODS: In this study, we investigated the mutational status of BRAF(V600E) , KIT, GNAQ, GNA11, N-RAS and H-RAS in a series of 19 primary melanocytic tumours of the central nervous system (CNS). RESULTS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System Neoplasms
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to MAP Kinase Signaling System

Share to Melanocytes

Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 22758774
DOI: 10.1111/j.1365-2990.2012.01288.x

Genes

GNA11
GNAQ
BRAF
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.PMID 22758774Read ↗

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.Semantic proximity Read ↗

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.Semantic proximity Read ↗

Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.Semantic proximity Read ↗

Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.Semantic proximity Read ↗

Mutations in GNA11 in uveal melanoma.Semantic proximity Read ↗

Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.Semantic proximity Read ↗

Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.Semantic proximity Read ↗

Immunohistochemical and molecular pathology of ocular uveal melanocytoma: evidence for somatic GNAQ mutations.Semantic proximity Read ↗

Lack of oncogenic GNAQ mutations in melanocytic lesions of the conjunctiva as compared to uveal melanoma.Semantic proximity Read ↗

Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.Semantic proximity Read ↗

Mutational profile of GNAQQ209 in human tumors.Semantic proximity Read ↗

Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.