Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.

Acta neuropathologica - 1 Mar 2010

Küsters-Vandevelde Heidi V N, Klaasen Annelies, Küsters Benno, Groenen Patricia J T A, van Engen-van Grunsven Ilse A C H, van Dijk Marcory R C F, Reifenberger Guido, Wesseling Pieter, Blokx Willeke A M

Abstract excerpt

Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived from melanocytes that normally can be found in the leptomeninges. They cover a spectrum of malignancy grades ranging from low-grade melanocytomas to lesions of intermediate malignancy and overtly malignant melanomas. Characteristic genetic alterations in this group of neoplasms have not yet been identified. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System Neoplasms
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Melanocytes

Share to Melanoma

Share to Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 19936769
DOI: 10.1007/s00401-009-0611-3
PMCID: PMC2831181

Genes

GNAQ
BRAF
HRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.PMID 19936769Read ↗

Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.Semantic proximity Read ↗

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.Semantic proximity Read ↗

Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.Semantic proximity Read ↗

Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysisSemantic proximity Read ↗

Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.Semantic proximity Read ↗

GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.Semantic proximity Read ↗

Genomic analysis reveals low tumor mutation burden which may be associated with GNAQ/11 alteration in a series of primary leptomeningeal melanomas.Semantic proximity Read ↗

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.Semantic proximity Read ↗

Mutation analysis of metastatic melanomas in the central nervous system: results of a panel of 5 genes in 48 cases.Semantic proximity Read ↗

Lack of oncogenic GNAQ mutations in melanocytic lesions of the conjunctiva as compared to uveal melanoma.Semantic proximity Read ↗

Immunohistochemical and molecular pathology of ocular uveal melanocytoma: evidence for somatic GNAQ mutations.Semantic proximity Read ↗

Mutations in GNA11 in uveal melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.