Article
Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.
Acta neuropathologica - 1 Mar 2010
Küsters-Vandevelde Heidi V N, Klaasen Annelies, Küsters Benno, Groenen Patricia J T A, van Engen-van Grunsven Ilse A C H, van Dijk Marcory R C F, Reifenberger Guido, Wesseling Pieter, Blokx Willeke A M
Abstract excerpt
Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived from melanocytes that normally can be found in the leptomeninges. They cover a spectrum of malignancy grades ranging from low-grade melanocytomas to lesions of intermediate malignancy and overtly malignant melanomas. Characteristic genetic alterations in this group of neoplasms have not yet been identified. Using...
Topics
- Adult
- Aged
- Central Nervous System Neoplasms
- Codon
- DNA, Neoplasm
- Female
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- Genes, ras
- Humans