Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.

Abstract excerpt

PURPOSE: To examine whether GNAQ and GNA11 somatic mutations previously identified in uveal melanomas of Caucasians are associated with uveal melanomas in Chinese patients. METHODS: Uveal melanomas treated by primary enucleation in Chinese patients underwent a mutation analysis of GNAQ and GNA11 with sequencing of exon 5 and exon 4. RESULTS: The study included 50 patients with uveal melanoma and with a mean age...

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