Article
Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
Ophthalmology - 1 Dec 2022
Solomon David A, Ramani Biswarathan, Eiger-Moscovich Maya, Milman Tatyana, Uludag Gunay, Crawford J Brooks, Phan Isabella, Char Devron H, Shields Carol L, Eagle Ralph C, Bastian Boris C, Bloomer Michele M, Pekmezci Melike
Abstract excerpt
OBJECTIVE: To analyze the genetic features of melanocytomas and melanomas of the anterior uvea and assess the value of molecular testing for diagnosis and prognostication. DESIGN: Retrospective case-control study. SUBJECTS: Patients with melanocytoma (n = 16) and melanoma (n = 19) of the anterior uvea. METHODS: Targeted next-generation sequencing was performed on formalin-fixed, paraffin-embedded tumor tissue...
Topics
- Humans
- GTP-Binding Protein alpha Subunits
- DNA Mutational Analysis
- Ciliary Body
- Retrospective Studies
- Case-Control Studies
- GTP-Binding Protein alpha Subunits, Gq-G11
- Uveal Neoplasms
- Melanoma