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Article

Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.

Journal of neuro-oncology - 1 May 2016

van de Nes Johannes, Gessi Marco, Sucker Antje, Möller Inga, Stiller Mathias, Horn Susanne, Scholz Simone L, Pischler Carina, Stadtler Nadine, Schilling Bastian, Zimmer Lisa, Hillen Uwe, Scolyer Richard A, Buckland Michael E, Lauriola Libero, Pietsch Torsten, Waha Andreas, Schadendorf Dirk, Murali Rajmohan, Griewank Klaus G

Abstract excerpt

Melanocytic tumors originating in the central nervous system (MT-CNS) are rare tumors that generally have a favorable prognosis, however malignant tumors do occur. Pathogenetically MT-CNS are not well characterized. Similar to uveal melanoma and blue nevi, they frequently harbor activating GNAQ or GNA11 mutations. Rare NRAS mutations have also been reported. Other mutations have not yet been described. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26744134
DOI: 10.1007/s11060-015-2052-2
PMCID: PMC5521190

Genes

GNA11
GNAQ
BAP1
NRAS
BRAF
RAC1

Provenance

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