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Article

Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.

Pathology oncology research : POR - 1 Oct 2019

Schneider Bjoern, Riedel Katrin, Zhivov Andrey, Huehns Maja, Zettl Heike, Guthoff Rudolf F, Jünemann Anselm, Erbersdobler Andreas, Zimpfer Annette

Abstract excerpt

Malignant melanoma of the uvea is the most common primary malignant tumor in the eye. We aimed to analyze GNAQ and GNA11 mutations in uveal melanomas using formalin-fixed, paraffin-embedded material and correlate the results with clinicopathological parameters. Tumor tissue was microdissected followed by amplification of GNAQ exon 4 and 5, GNA11 exon 4 and 5, and finally analyzed by Sanger sequencing. A total of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29209985
DOI: 10.1007/s12253-017-0371-7

Genes

GNAQ
GNA11

Provenance

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