Article
Mutations in GNA11 in uveal melanoma.
The New England journal of medicine - 2 Dec 2010
Van Raamsdonk Catherine D, Griewank Klaus G, Crosby Michelle B, Garrido Maria C, Vemula Swapna, Wiesner Thomas, Obenauf Anna C, Wackernagel Werner, Green Gary, Bouvier Nancy, Sozen M Mert, Baimukanova Gail, Roy Ritu, Heguy Adriana, Dolgalev Igor, Khanin Raya, Busam Klaus, Speicher Michael R, O'Brien Joan, Bastian Boris C
Abstract excerpt
BACKGROUND: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS: We sequenced exon 5 of GNAQ and GNA11, a paralogue of GNAQ, in 713 melanocytic neoplasms of different types (186 uveal melanomas, 139 blue nevi, 106 other nevi,...
Topics
- Animals
- Cells, Cultured
- DNA Mutational Analysis
- Exons
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- Humans
- Melanocytes
- Melanoma