Article
Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.
Pathology oncology research : POR - 1 Apr 2015
Küsters-Vandevelde Heidi V N, van Engen-van Grunsven Ilse A C H, Coupland Sarah E, Lake Sarah L, Rijntjes Jos, Pfundt Rolph, Küsters Benno, Wesseling Pieter, Blokx Willeke A M, Groenen Patricia J T A
Abstract excerpt
Limited data is available on the genetic features of primary leptomeningeal melanocytic neoplasms (LMNs). Similarities with uveal melanoma were recently suggested as both entities harbor oncogenic mutations in GNAQ and GNA11. Whether primary LMNs share additional genetic alterations with uveal melanoma including copy number variations is unknown. Twenty primary LMNs ranging from benign and intermediate-grade...
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