Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Nature - 29 Jan 2009

Van Raamsdonk Catherine D, Bezrookove Vladimir, Green Gary, Bauer Jürgen, Gaugler Lona, O'Brien Joan M, Simpson Elizabeth M, Barsh Gregory S, Bastian Boris C

Abstract excerpt

BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway. However, BRAF and NRAS mutations are absent in a number of other melanocytic neoplasms in which the equivalent oncogenic events are currently unknown. Here we report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to GTP-Binding Protein alpha Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Melanocytes

Share to Mitogen-Activated Protein Kinases

Share to Oncogenes

Share to ras Proteins

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 19078957
DOI: 10.1038/nature07586
PMCID: PMC2696133

Genes

GNAQ
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.PMID 19078957Read ↗

Mutational profile of GNAQQ209 in human tumors.Semantic proximity Read ↗

Mutations in GNA11 in uveal melanoma.Semantic proximity Read ↗

Frequent somatic mutations of GNAQ in uveal melanoma and blue naeviSemantic proximity Read ↗

GNAQ and GNA11 mutations in uveal melanoma.Semantic proximity Read ↗

Oncogenic mutations in GNAQ occur early in uveal melanoma.Semantic proximity Read ↗

Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.Semantic proximity Read ↗

GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal MelanomaSemantic proximity Read ↗

Novel somatic mutations in heterotrimeric G proteins in melanoma.Semantic proximity Read ↗

Ras, Raf, and MAP kinase in melanoma.Semantic proximity Read ↗

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.Semantic proximity Read ↗

GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.Semantic proximity Read ↗

Immunohistochemical and molecular pathology of ocular uveal melanocytoma: evidence for somatic GNAQ mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.