Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells

30 Jun 2012

Abstract excerpt

UNLABELLED: Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. We identify an important role for DDX5 in G(1)-S-phase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22750847
DOI: 10.1158/2159-8290.cd-12-0116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer CellsPMID 22750847Read ↗

DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defectsSemantic proximity Read ↗

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell ExpansionSemantic proximity Read ↗

Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent MannerSemantic proximity Read ↗

EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.Semantic proximity Read ↗

The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNASemantic proximity Read ↗

RNA helicases, DDX5 and DDX17, facilitate lytic reactivation of gammaherpesvirusesSemantic proximity Read ↗

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.Semantic proximity Read ↗

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stressSemantic proximity Read ↗

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Semantic proximity Read ↗

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathwaySemantic proximity Read ↗

Replication proteins and human disease.Semantic proximity Read ↗

CXXC5 is a ubiquitinated protein and is degraded by the ubiquitination-proteasome pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.