Article
An association between genotypic variations and protein expression of the glial glutamate transporter 2 in the human nucleus accumbens.
Neuroscience letters - 15 Aug 2012
Kerdsan Walailuk, Thanoi Samur, Nudmamud-Thanoi Sutisa, Reynolds Gavin P
Abstract excerpt
The glial glutamate transporter EAAT2 is responsible for the majority of synaptic glutamate clearance. Dysfunction of EAAT2 is strongly implicated in neuropsychiatric disorders. Single nucleotide polymorphisms (SNPs) in the EAAT2 gene have been associated with an increased risk of pathological conditions that may result from changes in extracellular glutamate levels. Genetic variation in the metabotropic...
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