Article
Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia.
Translational psychiatry - 9 Jun 2015
O'Donovan S M, Hasselfeld K, Bauer D, Simmons M, Roussos P, Haroutunian V, Meador-Woodruff J H, McCullumsmith R E
Abstract excerpt
Dysregulation of the glutamate transporters EAAT1 and EAAT2 and their isoforms have been implicated in schizophrenia. EAAT1 and EAAT2 expression has been studied in different brain regions but the prevalence of astrocytic glutamate transporter expression masks the more subtle changes in excitatory amino acid transporters (EAATs) isoforms in neurons in the cortex. Using laser capture microdissection, pyramidal...
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