Article

Expression of a modified astrocytic glutamate transporter alleviates Huntington’s hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions

2020-09-19

Abstract excerpt

<h4>SUMMARY</h4> Rapid removal of glutamate from the sites of glutamate release is an essential step in excitatory synaptic transmission. Despite many years of research, the molecular mechanisms underlying the intracellular regulation of glutamate transport at tripartite synapses have remained unclear. This limits the options for pharmacological treatment of motor disorders associated with glutamate excitotoxicit...

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Literature Corpus work: bdc7cbe1-399f-5dba-b78a-8bd4e949a2a6
DOI: 10.1101/2020.09.17.302158

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