Article
The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use - an exploratory study on a university student population.
Psychiatria polska - 30 Jun 2024
Dawidowski Bartosz, Olejniczak Barbara, Groblińska Katarzyna, Knapińska Magdalena, Kozicka Urszula, Krasiński Michał, Kułak Anna, Grelecki Grzegorz, Czaplińska Zuzanna, Piotrowska Oliwia, Kościelecka Klaudia, Podwalski Piotr, Michalczyk Anna, Samochowiec Jerzy
Abstract excerpt
OBJECTIVES: Evidence suggests that decreased dopamine secretion in mesocorticolimbic pathways could predispose to increased susceptibility to substance addiction. It has been proposed to define such a phenomenon as the reward deficit syndrome (RDS). Dopaminergic projections of the reward system receive glutaminergic projections from cortex. Research indicates that a reduction in the stimulating glutamatergic...
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