Article
Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence.
Psychiatric genetics - 1 Sept 2000
Sander T, Ostapowicz A, Samochowiec J, Smolka M, Winterer G, Schmidt L G
Abstract excerpt
Glutamate-mediated excitatory pathways play an important role in the pathogenesis of alcohol dependence. The present association study tested the candidate gene hypothesis that variation of the gene encoding the astroglial glutamate transporter EAAT2 confers vulnerability to alcohol dependence. Genotypes of a silent G603A nucleotide exchange in exon 5 of the EAAT2 gene were assessed in 565 subjects of German...
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