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Article

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma

1 Dec 2014

Abstract excerpt

Diffuse gliomas and secondary glioblastomas (GBMs) that develop from low-grade gliomas are a common and incurable class of brain tumor. Mutations in the metabolic enzyme glioblastomas (IDH1) represent a distinguishing feature of low-grade gliomas and secondary GBMs. IDH1 mutations are one of the most common and earliest detectable genetic alterations in low-grade diffuse gliomas, and evidence supports this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25434382
DOI: 10.3171/2014.9.focus14505

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