Article
IDH1 and IDH2 mutations in gliomas.
The New England journal of medicine - 19 Feb 2009
Yan Hai, Parsons D Williams, Jin Genglin, McLendon Roger, Rasheed B Ahmed, Yuan Weishi, Kos Ivan, Batinic-Haberle Ines, Jones Siân, Riggins Gregory J, Friedman Henry, Friedman Allan, Reardon David, Herndon James, Kinzler Kenneth W, Velculescu Victor E, Vogelstein Bert, Bigner Darell D
Abstract excerpt
BACKGROUND: A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas). METHODS: We determined the sequence of the IDH1 gene and the related IDH2 gene in...
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