Article
IDH mutation in glioma: new insights and promises for the future.
JAMA neurology - 1 Oct 2014
Turkalp Zorbey, Karamchandani Jason, Das Sunit
Abstract excerpt
IMPORTANCE: Over the past 4 years, our understanding of gliomagenesis and the practice of neuro-oncology have been radically changed by the discovery of mutations involving the isocitrate dehydrogenase (IDH) enzymes. IDH mutation has been found to be an inciting event in gliomagenesis and to have a profound effect on the molecular and genetic route of oncogenic progression and on clinical outcome. OBJECTIVES: To...
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