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Article

Isocitrate dehydrogenase mutations in gliomas.

Neuro-oncology - 1 Jan 2016

Waitkus Matthew S, Diplas Bill H, Yan Hai

Abstract excerpt

Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs). IDH enzymes normally catalyze the decarboxylation of isocitrate to generate...

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Source

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Identifiers

PMID: 26188014
DOI: 10.1093/neuonc/nov136
PMCID: PMC4677412

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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