Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.

PloS one - 1 Jan 2012

Klauke Benedikt, Winter Bernward, Gajewska Agnes, Zwanzger Peter, Reif Andreas, Herrmann Martin J, Dlugos Andrea, Warrings Bodo, Jacob Christian, Mühlberger Andreas, Arolt Volker, Pauli Paul, Deckert Jürgen, Domschke Katharina

Abstract excerpt

The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system--partly conferred by catechol-O-methyltransferase (COMT) gene variation--for the adenosinergic system as well as for early life trauma to constitute...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COMT gene

Share to Genotype

Share to Polymorphism, Genetic

Share to Reflex, Startle

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22745815
DOI: 10.1371/journal.pone.0039709
PMCID: PMC3382176

Genes

COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.PMID 22745815Read ↗

Multilevel impact of the dopamine system on the emotion-potentiated startle reflex.Semantic proximity Read ↗

COMT genetic variation affects fear processing: psychophysiological evidence.Semantic proximity Read ↗

ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex.Semantic proximity Read ↗

Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.Semantic proximity Read ↗

Influence of catechol-O-methyltransferase Val158Met polymorphism on startle response in the presence of high estradiol levels.Semantic proximity Read ↗

Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample.Semantic proximity Read ↗

The interaction of early life experiences with COMT val158met affects anxiety sensitivity.Semantic proximity Read ↗

Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.Semantic proximity Read ↗

Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm.Semantic proximity Read ↗

Affect-modulated startle reflex and dopamine D4 receptor gene variation.Semantic proximity Read ↗

The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.Semantic proximity Read ↗

Interaction between COMT Val158 Met polymorphism and childhood trauma predicts risk for depression in men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.