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Article

Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.

Psychopharmacology - 1 Aug 2012

Domschke Katharina, Klauke Benedikt, Winter Bernward, Gajewska Agnes, Herrmann Martin J, Warrings Bodo, Mühlberger Andreas, Wosnitza Katherina, Dlugos Andrea, Naunin Swantje, Nienhaus Kathrin, Fobker Manfred, Jacob Christian, Arolt Volker, Pauli Paul, Reif Andreas, Zwanzger Peter, Deckert Jürgen

Abstract excerpt

RATIONALE/OBJECTIVES: Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system has been suggested with administration of the adenosine A2A receptor antagonist caffeine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22399050
DOI: 10.1007/s00213-012-2678-0

Genes

NPS

Variants

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