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Article

Multilevel impact of the dopamine system on the emotion-potentiated startle reflex.

Psychopharmacology - 1 Jun 2015

Domschke Katharina, Winter Bernward, Gajewska Agnieszka, Unterecker Stefan, Warrings Bodo, Dlugos Andrea, Notzon Swantje, Nienhaus Kathrin, Markulin Falko, Gieselmann Astrid, Jacob Christian, Herrmann Martin J, Arolt Volker, Mühlberger Andreas, Reif Andreas, Pauli Paul, Deckert Jürgen, Zwanzger Peter

Abstract excerpt

RATIONALE/OBJECTIVES: The pathogenetic mechanism of emotion-related disorders such as anxiety disorders is considered to be complex with an interaction of genetic, biochemical, and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic system-partly conferred by catechol-O-methyltransferase (COMT) gene variation-and for distorted emotional processing to constitute risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25510857
DOI: 10.1007/s00213-014-3830-9

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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