Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample.

doi:10.1016/j.jad.2018.02.060

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Article

Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample.

Journal of affective disorders - 1 Jul 2018

Asselmann Eva, Hertel Johannes, Beesdo-Baum Katja, Schmidt Carsten-Oliver, Homuth Georg, Nauck Matthias, Grabe Hans-Jörgen, Pané-Farré Christiane A

Abstract excerpt

BACKGROUND: The single nucleotide polymorphism rs4680 of the catechol-O-methyltransferase (COMT) gene has been implicated to be involved in the etiopathogenesis of panic. However, it remains unresolved whether rs4680 modifies the risk-association between early life stress and subsequent development of panic pathology. METHODS: The genotype of rs4680 was determined for n = 2242 adults with European ancestry from...

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PMID: 29574383
DOI: 10.1016/j.jad.2018.02.060

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