Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm.

The international journal of neuropsychopharmacology - 1 Oct 2012

Armbruster Diana, Mueller Anett, Strobel Alexander, Lesch Klaus-Peter, Brocke Burkhard, Kirschbaum Clemens

Abstract excerpt

Dopamine and norepinephrine are key regulators of cognitive and affective processes. The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Additionally, stressful life events (SLEs) contribute substantially to affective processes. We used the stress-induced activation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Life Change Events

Share to Neuropsychological Tests

Share to Saliva

Share to Social Environment

Share to Stress, Psychological

Source

Identifiers

PMID: 22152146
DOI: 10.1017/S1461145711001763

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm.PMID 22152146Read ↗

Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress.Semantic proximity Read ↗

Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.Semantic proximity Read ↗

Catechol-O-Methyltransferase gene (val158met) polymorphisms and anxious symptoms in early childhood: The roles of hypothalamus-pituitary-adrenal axis reactivity and life stress.Semantic proximity Read ↗

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met GenotypesSemantic proximity Read ↗

Genetic contributions to acute autonomic stress responsiveness in children.Semantic proximity Read ↗

The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages.Semantic proximity Read ↗

The divergent impact of catechol-O-methyltransferase (COMT) Val158Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity.Semantic proximity Read ↗

The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.Semantic proximity Read ↗

Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.Semantic proximity Read ↗

Early life adversity and cardiovascular responses to repeated stress among adolescents: Moderating role of COMT gene rs4680 polymorphism.Semantic proximity Read ↗

Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ.Semantic proximity Read ↗

Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.