Article
Agonist trapped in ATP-binding sites of the P2X2 receptor.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Jiang Ruotian, Lemoine Damien, Martz Adeline, Taly Antoine, Gonin Sophie, Prado de Carvalho Lia, Specht Alexandre, Grutter Thomas
Abstract excerpt
ATP-gated P2X receptors are trimeric ion channels, as recently confirmed by X-ray crystallography. However, the structure was solved without ATP and even though extracellular intersubunit cavities surrounded by conserved amino acid residues previously shown to be important for ATP function were proposed to house ATP, the localization of the ATP sites remains elusive. Here we localize the ATP-binding sites by...
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