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Article

Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes.

Kidney international - 1 Oct 2012

Perianayagam Mary C, Tighiouart Hocine, Liangos Orfeas, Kouznetsov Diana, Wald Ron, Rao Fangwen, O'Connor Daniel T, Jaber Bertrand L

Abstract excerpt

Myeloperoxidase (MPO) is a lysosomal enzyme that may be involved in oxidative stress-mediated kidney injury. Using a two-step approach, we measured the association of four polymorphisms across the length of the MPO gene with systemic markers of oxidative stress: plasma MPO and urinary 15-F(2t)-isoprostane levels. Adverse outcomes were measured in a primary cohort of 262 adults hospitalized with acute kidney...

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Identifiers

PMID: 22739978
DOI: 10.1038/ki.2012.235
PMCID: PMC3461107

Genes

MPO

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Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes.PMID 22739978Read ↗

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