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Article

Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis?

Atherosclerosis - 1 Sept 2006

Chevrier Isabelle, Tregouet David-Alexandre, Massonnet-Castel Simone, Beaune Philippe, Loriot Marie-Anne

Abstract excerpt

OBJECTIVE: Myeloperoxidase (MPO), an abundant leukocyte hemoprotein has been linked to atherosclerosis and cardiovascular disease. We previously found new genetic polymorphisms in MPO gene. The purpose of this study was to evaluate the influences of these polymorphisms on human neutrophil MPO activity by means of haplotype analysis. METHODS AND RESULTS: Neutrophils from 102 blood donors were isolated and MPO...

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Identifiers

PMID: 16289072
DOI: 10.1016/j.atherosclerosis.2005.10.012

Genes

MPO

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