Article
A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
Kidney international. Supplement - 1 May 2003
Pecoits-Filho Roberto, Stenvinkel Peter, Marchlewska Alicia, Heimburger Olof, Bárány Peter, Hoff Catherine M, Holmes Clifford J, Suliman Mohamed, Lindholm Bengt, Schalling Martin, Nordfors Louise
Abstract excerpt
Cardiovascular disease (CVD) is the leading cause of mortality in end-stage renal disease (ESRD) patients and there is emerging evidence that genetic factors may contribute to the development of atherosclerosis. Myeloperoxidase (MPO) is an abundant enzyme involved in the production of free radicals. A functional G-->A single nucleotide polymorphism (SNP) has been identified at position -463, where the A allele is...
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