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Article

A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.

Journal of the American Heart Association - 27 Aug 2014

Waterworth Dawn M, Li Li, Scott Robert, Warren Liling, Gillson Christopher, Aponte Jennifer, Sarov-Blat Lea, Sprecher Dennis, Dupuis Josée, Reiner Alex, Psaty Bruce M, Tracy Russell P, Lin Honghuang, McPherson Ruth, Chissoe Stephanie, Wareham Nick, Ehm Margaret G

Abstract excerpt

BACKGROUND: Genetics can be used to predict drug effects and generate hypotheses around alternative indications. To support Losmapimod, a p38 mitogen-activated protein kinase inhibitor in development for acute coronary syndrome, we characterized gene variation in MAPK11/14 genes by exome sequencing and follow-up genotyping or imputation in participants well-phenotyped for cardiovascular and metabolic traits....

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Source

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Identifiers

PMID: 25164947
DOI: 10.1161/JAHA.114.001074
PMCID: PMC4310399

Genes

MAPK14
MAPK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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