Article
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Human molecular genetics - 15 Aug 2013
Reiner Alexander P, Hartiala Jaana, Zeller Tanja, Bis Joshua C, Dupuis Josée, Fornage Myriam, Baumert Jens, Kleber Marcus E, Wild Philipp S, Baldus Stephan, Bielinski Suzette J, Fontes João D, Illig Thomas, Keating Brendan J, Lange Leslie A, Ojeda Francisco, Müller-Nurasyid Martina, Munzel Thomas F, Psaty Bruce M, Rice Kenneth, Rotter Jerome I, Schnabel Renate B, Tang W H Wilson, Thorand Barbara, Erdmann Jeanette, Jacobs David R, Wilson James G, Koenig Wolfgang, Tracy Russell P, Blankenberg Stefan, März Winfried, Gross Myron D, Benjamin Emelia J, Hazen Stanley L, Allayee Hooman
Abstract excerpt
Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European ancestry and African Americans (AAs). A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene...
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