Article
Relevance of lysine snorkeling in the outer transmembrane domain of small viral potassium ion channels.
Biochemistry - 17 Jul 2012
Gebhardt Manuela, Henkes Leonhard M, Tayefeh Sascha, Hertel Brigitte, Greiner Timo, Van Etten James L, Baumeister Dirk, Cosentino Cristian, Moroni Anna, Kast Stefan M, Thiel Gerhard
Abstract excerpt
Transmembrane domains (TMDs) are often flanked by Lys or Arg because they keep their aliphatic parts in the bilayer and their charged groups in the polar interface. Here we examine the relevance of this so-called "snorkeling" of a cationic amino acid, which is conserved in the outer TMD of small viral K(+) channels. Experimentally, snorkeling activity is not mandatory for Kcv(PBCV-1) because K29 can be replaced...
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