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Article

Chikungunya virus E1 fusion loop-membrane interaction: Conserved residues and shallow insertion.

Biophysical journal - 3 Mar 2026

Gudigamolla Naresh Kumar, Das Birupaksha, Panda Preeti Pragya, Meher Geetanjali, Mohammed Saleem, Chowdary Tirumala Kumar

Abstract excerpt

Fusion of viral and cellular membranes, essential for entry of enveloped viruses, is mediated by viral fusion proteins (FPs). These proteins insert hydrophobic elements into target membranes to destabilize bilayers and drive fusion. For class I FPs, sequence and structural requirements of the fusion peptide are well characterized. In contrast, class II FPs, such as the alphavirus E1 glycoprotein, employ compact...

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Identifiers

PMID: 41618565
DOI: 10.1016/j.bpj.2026.01.045
PMCID: PMC13351907

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