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Article

Long distance interactions within the potassium channel pore are revealed by molecular diversity of viral proteins.

The Journal of biological chemistry - 2 Jul 2004

Gazzarrini Sabrina, Kang Ming, Van Etten James L, Tayefeh Sascha, Kast Stefan M, DiFrancesco Dario, Thiel Gerhard, Moroni Anna

Abstract excerpt

Kcv is a 94-amino acid protein encoded by chlorella virus PBCV-1 that corresponds to the pore module of K(+) channels. Therefore, Kcv can be a model for studying the protein design of K(+) channel pores. We analyzed the molecular diversity generated by approximately 1 billion years of evolution on kcv genes isolated from 40 additional chlorella viruses. Because the channel is apparently required for virus...

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Identifiers

PMID: 15105432
DOI: 10.1074/jbc.M401184200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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